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griPASTA could improve the quality and reproducibility of grip strength experiments by enabling researchers to obtain quantitative grip strength data in high resolution using a highly customizable platform. We propose griPASTA вЂ“ a simple and robust open-source grip strength platform made from an ordinary kitchen scale. Consequently, cheap semi-quantitative tests are often used at the expense of precision and reliability. Strain gauge-based grip strength meters provide the most reliable results, however, commercial solutions are unaffordable by many. Neuromuscular function analyzed by grip strength performance tests is an integral part of motor system neuroscience and neurotoxicology. Finally, the importance of bioinstrumental customization is demonstrated by utilizing griPASTA for assessment of trial speed from initial-to-maximal deflection time segments and controlling for its potential confounding effects on the grip strength. Furthermore, we test the griPASTA system for assessment of increased muscular rigidity in the proof-of-concept experiment in the rat model of ParkinsonвЂ™s disease induced by intrastriatal administration of 6-hydroxydopamine (6-OHDA).

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Here we demonstrate how to build a rodent grip strength apparatus from scratch using a digital kitchen scale, an empty cage, and a microcontroller, with both hardware and software being completely open-source to enable maximal modularity and flexibility of the instrument in concordance with the principles of open-source bioinstrumentation. Among methods used for quantification of grip performance in rodents, gauge-based grip strength meters provide the most reliable results, however, such instruments are unaffordable by many laboratories. Assessment of neuromuscular function is critical for understanding pathophysiological changes related to motor system dysfunction in many rodent disease models.

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